02. July 2025

Advancing personalized diagnostics in cardiovascular diseases Advancing personalized diagnostics in cardiovascular diseases

ACRIBiS Concept Paper published

Personalized risk assessments are considered key to improving prevention and treatment of cardiovascular diseases. What has been lacking so far is a standardized infrastructure. Since 2023, a consortium of German research institutions has been working on exactly that within the ACRIBiS project (Advancing Cardiovascular Risk Identification with Structured Clinical Documentation and Biosignal Derived Phenotypes Synthesis). The project’s concept paper has now been published in the European Heart Journal – Digital Health.

Graphical abstract of the ACRIBiS project
Graphical abstract of the ACRIBiS project © Felbel, Prüser, Schmidt et al. 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.
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One of ACRIBiS's main goals is to more accurately identify individual patient risks and to derive well-founded decisions for prevention, diagnostics, and therapy. Teams at 17 locations across Germany are working toward this by establishing structured and standardized clinical documentation and systematically utilizing biosignal data — such as electrocardiograms (ECGs).

As part of the ACRIBiS cohort study, researchers are systematically collecting and analyzing clinical routine data and biosignals from approximately 4,500 patients. The combination of standardized documentation, biosignal analysis, and a shared technical infrastructure represents a novel approach. Among other benefits, this setup allows for continuous, real-time, cross-site quality monitoring of the risk models being developed.

Interested readers can now access a detailed description of ACRIBiS’s approach in the newly published concept paper. One key early result included in the paper is the jointly developed standardized clinical documentation framework. This is designed to both strengthen health services research in Germany and support international standardization efforts.
“With this publication, our highly innovative concept becomes accessible to the broader research community for the first time,” says Sven Zenker, Medical Director of the Office for Medical-Scientific Technology Development and Coordination (MWTek) and Head of the Applied Medical Informatics (AMI) working group at the Institute for Medical Biometry, Informatics and Epidemiology (IMBIE) at University Hospital Bonn. “It can contribute to the advancement of international standards in cardiology—especially in light of the upcoming launch of the European Health Data Space (EHDS).”

The publication is available here: academic.oup.com/ehjdh/advance-article/doi/10.1093/ehjdh/ztaf075/8178216 

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