The loss of interest or pleasure in normally enjoyable activities, which is experienced in everyday life and can be very distressing, is a core symptom of major depression. However, it has remained unclear exactly how anhedonia, also known as a pleasure deficit, manifests itself. Researchers at the University Hospital Bonn (UKB), the University of Bonn, and the University Hospital Tübingen have found that people with depression do not perceive food as less rewarding when they actually consume it. The differences compared to people without depression emerge during anticipation: how much they want something before they receive it. This reduced desire is also linked to the clinical severity of anhedonia. The study’s findings have now been published in the journal “Cell Reports Medicine.”

Mild brain injuries, such as those often sustained in accidents, sports or violence can lead to persistent memory problems and an increased risk of dementia. However, there are currently no therapies available to treat these consequences. A research team led by the University Hospital Bonn (UKB) and the University of Bonn has now discovered that the protein ASC – a component of cellular emergency buttons – causes long-lasting inflammation in the brains of mice for up to 21 days after injury. By elucidating the inflammatory mechanisms underlying traumatic brain injury, the research team hopes to identify starting points for future therapeutic strategies. The work published in the Journal of Clinical Investigation lays the foundation for future clinical studies.

How do our genes determine our appearance and our susceptibility to disease? This question is central to biomedical research, and today we can sequence thousands of human genomes to identify these genes. However, genes work in complex networks. In a major transdisciplinary collaboration, an international team of geneticists and bioinformaticians set out to create a so-called genetic interaction (GI) map of a human cell. With significant contributions from the Canadian Donnelly Centre, the University of Minnesota, the Hospital for Sick Children in Canada, the University Hospital Bonn, and the University of Bonn, a first draft has now been published in the journal Cell. This draft currently covers about 2.5 percent of all possible gene pairs. 

Myofibrillar myopathy type 6 (MFM6) is a rare genetic muscle disorder that leads to severe muscle weakness and a drastically shortened life expectancy due to a disruption in muscle protein regulation. Researchers at the University Hospital Bonn (UKB) and the University of Bonn developed a mouse model for the disease and were thus able to show that a disruption in cellular recycling—known technically as autophagy—is the primary trigger for the disease. Their findings have been published in the journal Nature Communications.

How can waste separation be implemented sustainably in the lab? What role can IT infrastructure play in resource-efficient research? And what specific opportunities do the University and the UKB already offer for conducting research in a more sustainable manner?

If humans or animals eat something that causes them to feel unwell, they subsequently avoid this food source. Until now, it has been unclear precisely how this avoidance learning takes place. A new study shows that communication between the brain cells and fat cells could play a crucial role here. The participants from the Universities of Bonn and Tohoku (Japan) and University Hospital Bonn have revealed the previously unknown mechanism in the fruit fly Drosophila. It may also exist in a similar form in mammals and even in humans. The results have now been published in the journal Neuron. 

In late March, a high-ranking delegation from the Canadian Western University visited the University of Bonn to expand existing relationships, particularly in the field of neuroscience, and form new collaborations in an array of disciplines.

The University of Bonn is cordially inviting all graduates to the Universitätsfest 2026! The event is being held on Saturday, July 11, 2026 at KUNST!RASEN on the Rheinaue park lawn for the first time. Prior registration is obligatory and open from noon on March 16, 2026 to May 31, 2026.