Welcome to the Medical Faculty of the University of Bonn
We are 1 of 7 faculties of the University of Bonn and affiliated to the transdisciplinary research area Life and Health. We maintain extensive partnerships with institutions of the Helmholtz Association, the Max Planck Society, and national and international research associations in the life sciences.
We are committed to outstanding, nationally and internationally visible translational research from basic sciences to patient care, as well as to teaching and training students closely linked to science to become competent and empathetic physicians.
Both tasks are fulfilled in close cooperation with the University Hospital and with respect for our employees.
"Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study by the University of Bonn now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism. The results were published online in advance. The final version has now been published in the journal "Molecular & Cellular Proteomics."
The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral infections. Strikingly, if TBK1 is not expressed at all, this clinical effect is not seen. The mechanism behind this supposed discrepancy has now been elucidated by researchers led by Prof. Martin Schlee from the University Hospital Bonn and the Cluster of Excellence ImmunoSensation2 at the University of Bonn. The study was published in the journal Frontiers in Immunology.
The success of cancer treatment depends not only on the type of tumor, but also on the surrounding tissue. Tumors influence it to their advantage, promoting the growth of blood vessels or fooling incoming immune cells. Developing methods to predict the nature of the resulting tumor microenvironment is the goal of researchers from the Clusters of Excellence ImmunoSensation2 and the Hausdorff Center for Mathematics (HCM) led by Prof. Kevin Thurley at the University of Bonn. The German Federal Ministry of Education and Research (BMBF) is funding the "InterpretTME" project with around 800,000 euros over the next three years.
In epilepsy research, it has long been assumed that a leaky blood-brain barrier is a cause of inflammation in the brain. Using a novel method, researchers from the University of Bonn an the Bonn University Hospital (UKB) have demonstrated that the barrier between the blood and the central nervous system remains largely intact. The approach of their study provides important insights into the development of epilepsy and could significantly optimize drug development in the pharmaceutical industry. The study results have recently been published in the journal Nature Communications.
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