Welcome to the Medical Faculty of the University of Bonn

Two projects by researchers from the University of Bonn and University Hospital Bonn (UKB) have each been awarded up to €1 million in funding from the Federal Ministry of Research, Technology and Space’s “GO-Bio initial” program. The funds will be used to translate research findings from the life sciences into marketable products and services, e.g. through securing patent protection and spinning off start-ups.

MOG Antibody-associated Disease (MOGAD) is a rare autoimmune disease of the central nervous system. The blood of patients contains antibodies against myelin oligodendrocyte glycoprotein (MOG), a protein in the myelin layer that surrounds the neurons in the brain. It is believed that these antibodies contribute to the destruction of this protective layer in the brain. Researchers at the University Hospital Bonn (UKB) and the Universities of Basel and Bonn, in collaboration with Yale School of Medicine and the German Center for Neurodegenerative Diseases (DZNE), have now deciphered the construction plan of the anti-MOG antibodies. The researchers see their findings on the misdirected immune response, which have now been published in the journal Neurology® Neuroimmunology & Neuroinflammation, as the basis for developing specific MOGAD therapies.

If gut bacteria are too similar to the protective layer of nerves, they can misdirect the immune system and cause it to attack its own nervous system. This mechanism can accelerate the progression of multiple sclerosis, as researchers at the University of Basel, together with colleagues in Bonn, have shown in trials with mice. However, their results also open up opportunities for treatments that make use of the microbiome. The results have now been published in the journal Gut Microbes.

The finalists presented innovative solutions for a better future at the University of Bonn's 5th ideas competition. A total of seven teams of students and researchers from the university made it through the preliminary selection and pitched their ideas to a packed hall and an expert jury at DIGITALHUB. Four of them ultimately received prizes from the jury and—for the first time—from the audience, which were donated by the University Foundation Bonn, Comma Soft AG, DIGITALHUB.DE, and Sparkasse KölnBonn.