While the adequate surgical treatment of cataract is guaranteed in high-income countries, the surgical results in the Global South are often inadequate. Video recording can be used to analyze possible surgical errors, improve training and demonstrably optimize surgical results. However, this has been very time-consuming up to now. There are now promising approaches to automating surgical video analysis using artificial intelligence (AI). However, no deep learning algorithms have yet been developed for video analysis of the surgical method commonly used in countries of the Global South. Researchers from the University Hospital Bonn, the University of Bonn, the Sankara Eye Foundation India and Microsoft Research India want to change this and develop a corresponding algorithm. The aim is to improve the results of cataract surgery in the Global South in the long term. As a first important step, they have compiled an overview of previous AI approaches for analyzing cataract surgeries. The results have now been published in Translational Vision Science and Technology (TVST).

The University of Bonn did very well in the QS World University rankings released yesterday, being amongst the top 100 worldwide in roughly a third of the ranked Subjects. Mathematics is again our highest-ranking subject (41st internationally, 1st in Germany).

Many kidney diseases are manifested by protein in the urine. However, until now it was not possible to determine whether the protein excretion is caused by only a few, but severely damaged, or by many moderately damaged of the millions of small kidney filters, known as glomeruli. Researchers at the University Hospital Bonn, in cooperation with mathematicians from the University of Bonn, have developed a new computer method to clarify this question experimentally. The results of their work have now been published as an article in press in the leading kidney research journal "Kidney International".

The 6th Pint of Science invites all interested scientists to participate.

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer. Researchers from the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn investigated the underlying mechanisms of Tfh cell development in a mouse model and thus decoded their internal networking. They hope that this will lead to new strategies for the development of highly effective vaccines and new therapies to combat various diseases. The results have now been published in the renowned journal "Science Immunology".
 
 

When people lack visual imagination, this is known as aphantasia. Researchers from the University Hospital Bonn (UKB), the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE) investigated how the lack of mental imagery affects long-term memory. They were able to show that changes in two important brain regions, the hippocampus and the occipital lobe, as well as their interaction, have an influence on the impaired recall of personal memories in aphantasia. The study results, which advance the understanding of autobiographical memory, have now been published online by the journal "eLife".

Researchers at the University Hospitals of Dresden and Bonn of the DFG Transregio 237 and from the Cluster of Excellence ImmunoSensation2 at the University of Bonn have made progress clarifying why patients with myotonic dystrophy 2 have a higher tendency to develop autoimmune diseases. Their goal is to understand the development of the disease, and their research has provided new, potential therapeutic targets. The results of the study have now been published in the renowned journal "Nature Communications".
 
 

Researchers from Carnegie Mellon University, the University Hospital Bonn and the University of Bonn have created an open-source platform known as A-SOiD that can learn and predict user-defined behaviors, just from video. The results of the study have now been published in the journal "Nature Methods".