Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction. In cooperation with Nanyang Technological University Singapore and the University Hospital Würzburg, among others, the study provides an explanation for how a point mutation in the immune receptor RIG-I transforms the body's defense system into a self-destructive force and causes severe organ-specific autoimmune diseases. The results have now been published in the journal Science Immunology.

How do the circuits of the human brain work – and what happens when they are disrupted? To investigate these questions, researchers at the Eye Clinic of the University Hospital Bonn (UKB) and the University of Bonn, together with colleagues from the University of Münster and Harvard Medical School, have developed an innovative platform that allows the function of neural networks to be studied in a targeted manner. The results have now been published in the journal ACS Nano.

Will it be possible to treat severe kidney inflammation with fewer drugs in the future? A new study by the University Hospital Bonn (UKB), the University of Bonn, and the University of Hamburg gives cause for hope. The researchers show that even low, repeated doses of steroids could be enough to stop inflammation in particularly aggressive crescentic glomerulonephritis (cGN). The findings, which have now been published in Science Translational Medicine, could fundamentally change the treatment of many patients – and significantly reduce side effects.

What effects does severe obesity have on the lungs? A research team led by Prof. Dr. Veronika Lukacs-Kornek from the ‘ImmunoSensation2’ Cluster of Excellence at the University of Bonn and the Institute for Molecular Medicine and Experimental Immunology (IMMEI) at the University Hospital Bonn (UKB) investigated this question. The results suggest that obesity causes the lungs to age faster. The findings have been published in the journal ‘Cell Reports’.

The University of Bonn is continuously expanding its research infrastructure – thereby creating the foundation for the success of its researchers. Under the umbrella of the Bonn Technology Campus (BTC), 14 core facilities are now available for university-wide use, combining cutting-edge technologies, specialized expertise, and comprehensive services. They provide all researchers at the university with access to instruments and methods that would often be inaccessible or difficult to obtain for individual research groups. In doing so, the University of Excellence creates the conditions necessary to put research ideas into practice at the highest level.

On August 29, the University Hospital Bonn (UKB) held its largest summer festival to date. The Vice Dean’s Office for Sustainability, together with ukb green, was once again represented with an information booth dedicated to the topic of sustainability.

Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue. That is why a team led by researchers from the University Hospital Bonn (UKB) and the University of Bonn investigated the influence of primary cilia dysfunction on adipocyte precursor cells in a mouse model. They found that overactivation of the Hedgehog signaling pathway causes abnormal development into connective tissue-like cells instead of white fat cells. Their findings have now been published in The EMBO Journal.

Emergencies, night shifts, high-pressure decision-making ... it takes more than specialized knowledge to work in medicine. That’s why the University of Bonn Faculty of Medicine offers courses specifically designed to help students become more mentally resilient, in cooperation with Jung-Stilling Siegen Hospital—a protestant social services clinic. Extreme athlete Joey Kelly returned as one of this year’s special course participants at University Hospital Bonn (UKB) and in Siegen, who did a night hike with outdoor sleeping together with students.