WHAT IS IT ABOUT?
The study investigates how the lungs adapt to nutritional challenge in obesity. The research team shows that obesity remodels the extracellular matrix in the lungs – the protein-based ‘scaffolding’ that gives the lungs their shape and stability. These changes in lung tissue are similar to those that normally occur with age and suggest that being overweight causes the lungs to ‘age’ prematurely.
HOW DID THEY PROCEED?
The team used state-of-the-art multi-omics approaches to simultaneously examine proteins, fats and genes for specific questions. They combined this analysis with microscopic image analyses and experiments that show how the lungs actually work. The researchers compared the lungs of obese and lean mice, analysed human connective tissue cells in the lungs, and took a close look at the composition of the lungs – enabling them to understand both molecular and functional changes.
WHAT IS THE KEY FINDING?
In obesity, lung fibroblasts, i.e. connective tissue cells, specifically accumulate fat, become more mobile and show early signs of premature ageing. At the same time, the matrisome, the ‘scaffolding’ of the lung, changes and the balance of certain protease inhibitor is disrupted. These changes make the lungs less elastic, which could explain why obesity is often associated with breathing difficulties. Interestingly, these changes are similar to those normally seen in older people – pointing to obesity as a driver of accelerated lung aging.
WHAT WAS THE BIGGEST CHALLENGE?
One of the biggest challenges was developing methods to analyse the complex connective tissue of the lungs – the so-called fibroblastic stroma – which consists of many different cell types. In addition, the extracellular matrix is also difficult to study because many of its proteins are insoluble and have a very complex structure.
WHAT IS THE SOURCE?
Sophia Rottmann, Jian Li, Jelena Zurkovic, Pablo Sierra Bravo, Andreas U. Lindner, Jie Qin, Sebastian Kallabis, Qi Mei, Xiansheng Liu, Christoph Thiele, Christoph Eckert, Felix Meissner, Veronika Lukacs-Kornek. Global matrisome changes in obese lung are linked to fibroblastic stroma and premature aging. Cell Reports (2025). DOI: 10.1016/j.celrep.2025.116285