The transport of substances across the membrane into the cell is linked to specific membrane transport proteins. Researchers at the University Hospital Bonn (UKB) and the University of Bonn, in collaboration with an international team, have now succeeded in elucidating the molecular structure of a completely new class of such membrane transporters. In addition to the Bonn scientists, researchers from the University of York were also involved. The study has now been published in the journal Nature Communications.

In the Middle Ages, every city had its own system of measurement. Even today, you can sometimes find iron rods in marketplaces that determined the length measurement valid for the city at that time. In science, however, there is no room for such uncertainties, and no matter what method you use to measure the length of a molecule, for example, the answer should always be the same. Researchers at the University Hospital Bonn (UKB), the University of Bonn and Ludwig-Maximilians-Universität (LMU) Munich have now investigated whether this is true for two methods that are very often used to measure distances in protein molecules - for example, to find out how such molecules move. The study has now appeared in the journal Nature Communications.

In severe Covid-19 patients, the metabolism produces insufficient amounts of certain energy-rich compounds called ketone bodies. However, these energy carriers are needed by two important cell types in the immune system in order to fight the virus effectively. Perhaps this finding explains why some people fall ill so much more severely than others. A study led by the University of Bonn and the University Hospital Bonn at least points in this direction. The results have now been published in the journal Nature. They also give hope for new therapies.

Are you excited about the possibility that your research could make a difference in the world?. We'd like to help you achieve that with awards totaling EUR 60.000! All you have to do is apply and present your idea at the first ever Bonn Medical Pitch Contest on September 15, 2022.

During sperm production, an enormous amount of DNA has to be packed into a very small space without breaking anything. A central role is played by certain proteins around which the DNA thread is wrapped - the protamines. A recent study by the University of Bonn provides new insights into this important mechanism. The results have been published in the journal PLoS Genetics.

A study led by the University of Bonn and the University Hospital Bonn has identified a molecule - the purine inosine - that boosts fat burning in brown adipocytes. The mechanism was discovered in mice, but probably exists in humans as well: If a transporter for inosine is less active, the mice remain significantly leaner despite a high-fat diet. The study, which also involved researchers from the University of Leipzig and the University Medical Center Hamburg-Eppendorf, has now been published in the journal Nature.
 

NeurotechEU, the European University of Brain and Technology, has invited its members to attend its semi-annual Board of Rectors meeting at Iuliu Hațieganu Medical and Pharmaceutical University in Cluj-Napoca, Romania. In May a delegation from the University of Bonn Rectorate attended this meeting of the top governance board of the consortium to which the former is a member, called to inaugurate the second project phase.

Redness, swelling, pain - these are signs of inflammation. It serves to protect the body from pathogens or foreign substances. Researchers from the Universities of Bonn and Cologne were able to show that inflammatory reactions of an important sensor protein proceed in a specific spatial direction. This finding has the potential to conceivably stop inflammation at the "growing end", and thus bring chronic inflammatory diseases to a halt. The study has now been published in the journal "Science Advances".