Core Facility Zebrafish

Short introduction and presentation of the Core Facility.

Getting started

Service & Costs

Instruments

Publications

Contact

Getting started

The zebrafish vertebrate modell offers countless possibilities for (in vivo) development and physiological research, such as disease models, toxicity tests, cell migration as well as human tumor cell (xenograft) studies.

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Services & Costs

Here is an overview of some of the facility’s offered services such as keeping zebrafish lines, injections into zebrafish eggs, cell transplantation and so on.

Also with a short cost information.

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Equipment & Instruments

The Zebrafish Core Facility consists of 200 fully maintained 3.5. litre tanks in 4 racks for keeping up to 4000 adult zebrafish (max. 20 per tank) for our customers availbility. Adidtionnaly to these fish-rack systems we also provide fish-breeding equipment, inkubators as well as air-pressuerd stereomikroskope injection set-ups and advanced fish-specific in vivo fluorescent imaging mikroscopes for the developing larvar fish.

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Do you have any questions?

FAQ

Answers to frequently asked questions about the PPMS booking system, the billing of core facility services and much more can be found in our FAQ section on Confluence.

Link

Counseling

Are you interested in our services? Please get in touch with the relevant contact person or send us an e-mail: Funktionsadresse@uni-bonn.de

Link

Acknowledgement

You would like to publish your results but do not know how to take the support of the Core Facility into account? Here you will find detailed instructions.

Link

Needful Links

Zebrafish Model Oranism Database

Zebrafish Disease Models Society

Bonn Technology Campus

Rehoming at the University Bonn

internal research funding

BTC-Cloud

Events

Wednesday Jun 25, 2025

ThemeNight: Zebrafish

Karl-Schilling ...

05:00 PM - 07:00 PM

Join us for another ThemeNight, jointly organized by the Bonner Forum Biomedizin, the Bonn Technology Campus, the TRA Life & Health and the Postdoc-Orga team ...

News from the Core Facility / Science news

The Core Facilities at the University of Bonn have a lot to offer

The University of Bonn is continuously expanding its research infrastructure – thereby creating the foundation for the success of its researchers. Under the umbrella of the Bonn Technology Campus (BTC), 14 core facilities are now available for university-wide use, combining cutting-edge technologies, specialized expertise, and comprehensive services. They provide all researchers at the university with access to instruments and methods that would often be inaccessible or difficult to obtain for individual research groups. In doing so, the University of Excellence creates the conditions necessary to put research ideas into practice at the highest level.

Fish to help in search for MS drugs

The zebrafish serves as a model organism for researchers around the world: it can be used to study important physiological processes that also take place in a similar form in the human body. It is therefore routinely used in the search for possible active substances against diseases. Researchers at the University of Bonn have now described an innovative way to do this. In this process, the larvae fish are made a bit more "human-like". This humanization could make the search for active pharmaceutical substances much more efficient. The results of the pilot study have been published in the journal Cell Chemical Biology.

Publications

2025

Kalanithy, Jeshurun C.; Mingardo, Enrico; Stegmann, Jil D.; Dhakar, Ramgopal; Dakal, Tikam Chand; Rosenfeld, Jill A. et al. (2025): TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies. In: Journal of Medical Genetics 62 (2), S. 126–137. DOI: 10.1136/jmg-2023-109799 .

2024

Ishorst, Nina; Hölzel, Selina; Greve, Carola; Yilmaz, Öznur; Lindenberg, Tobias; Lambertz, Jessica et al. (2024): Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models. In: European journal of human genetics : EJHG. DOI: 10.1038/s41431-024-01775-9 .

Mingardo, Enrico; Kalanithy, Jeshurun C.; Dworschak, Gabriel; Ishorst, Nina; Yilmaz, Öznur; Lindenberg, Tobias et al. (2024): EZH2 specifically regulates ISL1 during embryonic urinary tract formation. In: Sci Rep 14 (1), S. 22909. DOI: 10.1038/s41598-024-74303-w .

Stegmann, Jil D.; Kalanithy, Jeshurun C.; Dworschak, Gabriel C.; Ishorst, Nina; Mingardo, Enrico; Lopes, Filipa M. et al. (2024): Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies. In: npj Genom. Med. 9 (1), S. 18. DOI: 10.1038/s41525-024-00398-9 .

2023

Enders, Michael; Weier, Alicia; Chunder, Rittika; An, Young; Bremm, Franziska; Feigenspan, Andreas et al. (2023): Impact of the Voltage-Gated Calcium Channel Antagonist Nimodipine on the Development of Oligodendrocyte Precursor Cells. In: International Journal of Molecular Sciences 24 (4). DOI: 10.3390/ijms24043716 .

Harder, Alexander; Nagarajan, Bhuvaneswari; Odermatt, Benjamin; Kubitscheck, Ulrich (2023): Automatic detector synchronization for long-term imaging using confocal light-sheet microscopy. In: Microscopy research and technique 86 (2), S. 125–136. DOI: 10.1002/jemt.24223 .

Kolvenbach, Caroline M.; Felger, Tim; Schierbaum, Luca; Thiffault, Isabelle; Pastinen, Tomi; Szczepańska, Maria et al. (2023): X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems. In: Journal of Medical Genetics 60 (6), S. 587–596. DOI: 10.1136/jmg-2022-108738 .

Reinhardt, Florian; Coen, Luisa; Rivandi, Mahdi; Franken, André; Setyono, Eunike Sawitning Ayu; Lindenberg, Tobias et al. (2023): DanioCTC: Analysis of Circulating Tumor Cells from Metastatic Breast Cancer Patients in Zebrafish Xenografts. In: Cancers 15 (22). DOI: 10.3390/cancers15225411 .

2022

Häberlein, Felix; Mingardo, Enrico; Merten, Nicole; Schulze Köhling, Nina-Katharina; Reinoß, Philip; Simon, Katharina et al. (2022): Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs. In: Cell chemical biology 29 (10), 1541-1555.e7. DOI: 10.1016/j.chembiol.2022.08.007 .

Wilms, Christina; Lepka, Klaudia; Häberlein, Felix; Edwards, Steven; Felsberg, Jörg; Pudelko, Linda et al. (2022): Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism. In: Redox biology 49, S. 102221. DOI: 10.1016/j.redox.2021.102221 .