Core Facility Zebrafish

Short introduction and presentation of the Core Facility.
Zebrafish Core Logo
© Medienabteilung Ukbonn
Dozent im Seminar
© Rolf Müller

Getting started

The zebrafish vertebrate modell offers countless possibilities for (in vivo) development and physiological  research, such as disease models, toxicity tests, cell migration as well as human tumor cell (xenograft) studies.
Vorlesung
© Volker Lannert

Services & Costs

Here is an overview of some of the facility’s offered services such as keeping zebrafish lines, injections into zebrafish eggs, cell transplantation and so on.
Also with a short cost information.
Prof. Tchumatchenko
© Volker Lannert

Equipment & Instruments

The Zebrafish Core Facility consists of 200 fully maintained 3.5. litre tanks in 4 racks for keeping up to 4000 adult zebrafish (max. 20 per tank) for our customers availbility. Adidtionnaly to these fish-rack systems we also provide fish-breeding equipment, inkubators as well as air-pressuerd stereomikroskope injection set-ups and advanced fish-specific in vivo fluorescent imaging mikroscopes for the developing larvar fish.

Do you have any questions?

FAQ

Answers to frequently asked questions about the PPMS booking system, the billing of core facility services and much more can be found in our FAQ section on Confluence.

Counseling

Are you interested in our services? Please get in touch with the relevant contact person or send us an e-mail: Funktionsadresse@uni-bonn.de

Acknowledgement

You would like to publish your results but do not know how to take the support of the Core Facility into account? Here you will find detailed instructions.

Needful Links

Events
ThemeNight: Zebrafish
Karl-Schilling ...
05:00 PM - 07:00 PM
Join us for another ThemeNight, jointly organized by the Bonner Forum Biomedizin, the Bonn Technology Campus, the TRA Life & Health and the Postdoc-Orga team ...

Publications

Kalanithy, Jeshurun C.; Mingardo, Enrico; Stegmann, Jil D.; Dhakar, Ramgopal; Dakal, Tikam Chand; Rosenfeld, Jill A. et al. (2025): TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies. In: Journal of Medical Genetics 62 (2), S. 126–137. DOI: 10.1136/jmg-2023-109799 .

Ishorst, Nina; Hölzel, Selina; Greve, Carola; Yilmaz, Öznur; Lindenberg, Tobias; Lambertz, Jessica et al. (2024): Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models. In: European journal of human genetics : EJHG. DOI: 10.1038/s41431-024-01775-9 .

Mingardo, Enrico; Kalanithy, Jeshurun C.; Dworschak, Gabriel; Ishorst, Nina; Yilmaz, Öznur; Lindenberg, Tobias et al. (2024): EZH2 specifically regulates ISL1 during embryonic urinary tract formation. In: Sci Rep 14 (1), S. 22909. DOI: 10.1038/s41598-024-74303-w .

Stegmann, Jil D.; Kalanithy, Jeshurun C.; Dworschak, Gabriel C.; Ishorst, Nina; Mingardo, Enrico; Lopes, Filipa M. et al. (2024): Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies. In: npj Genom. Med. 9 (1), S. 18. DOI: 10.1038/s41525-024-00398-9 .

Enders, Michael; Weier, Alicia; Chunder, Rittika; An, Young; Bremm, Franziska; Feigenspan, Andreas et al. (2023): Impact of the Voltage-Gated Calcium Channel Antagonist Nimodipine on the Development of Oligodendrocyte Precursor Cells. In: International Journal of Molecular Sciences 24 (4). DOI: 10.3390/ijms24043716 .

Harder, Alexander; Nagarajan, Bhuvaneswari; Odermatt, Benjamin; Kubitscheck, Ulrich (2023): Automatic detector synchronization for long-term imaging using confocal light-sheet microscopy. In: Microscopy research and technique 86 (2), S. 125–136. DOI: 10.1002/jemt.24223 .

Kolvenbach, Caroline M.; Felger, Tim; Schierbaum, Luca; Thiffault, Isabelle; Pastinen, Tomi; Szczepańska, Maria et al. (2023): X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems. In: Journal of Medical Genetics 60 (6), S. 587–596. DOI: 10.1136/jmg-2022-108738 .

Reinhardt, Florian; Coen, Luisa; Rivandi, Mahdi; Franken, André; Setyono, Eunike Sawitning Ayu; Lindenberg, Tobias et al. (2023): DanioCTC: Analysis of Circulating Tumor Cells from Metastatic Breast Cancer Patients in Zebrafish Xenografts. In: Cancers 15 (22). DOI: 10.3390/cancers15225411 .

Häberlein, Felix; Mingardo, Enrico; Merten, Nicole; Schulze Köhling, Nina-Katharina; Reinoß, Philip; Simon, Katharina et al. (2022): Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs. In: Cell chemical biology 29 (10), 1541-1555.e7. DOI: 10.1016/j.chembiol.2022.08.007 .

Wilms, Christina; Lepka, Klaudia; Häberlein, Felix; Edwards, Steven; Felsberg, Jörg; Pudelko, Linda et al. (2022): Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism. In: Redox biology 49, S. 102221. DOI: 10.1016/j.redox.2021.102221 .

Contact

Avatar Odermatt

Prof. Dr. Benjamin Odermatt

Scientific Head of the Core Facility

Institute of Anatomy, 1st floor, rooms O-11.2

Nussallee 10

53115 Bonn

Avatar Lindenberg

Tobias Lindenberg

Core Facility Manager

Institute of Anatomy, 1st floor, rooms O-10

Nussallee 10

53115 Bonn

Acknowledgements

Administration Medical Faculty

Documents

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