Flow Cytometry Core Facility

The Flow Cytometry Core Facility (FCCF) at the University Hospital Bonn offers advanced flow cytometry services, including cell analysis and sorting, to researchers across various disciplines. The facility is equipped with state-of-the-art instruments, such as the BD FACSDiscover™S8 cell sorter an ImageStream® MarkII and two Sony ID7000™spectral analyzers, as well as classical instruments like the BD FACSCanto™II and LSRFortessa™ a FACSAria™Fusion and FACSAria™III and other instruments (comprehensive list: Instrument). These tools enable comprehensive analysis of cellular characteristics and efficient sorting of specific cell populations for further study. Additionally, the FCCF provides training, consultation, and support in experimental design and data analysis, ensuring researchers can effectively utilize these technologies for their scientific investigations

Online-Scheduling

Getting started

Events

Costs

Publications

Contact

Instruments

The Flow Cytometry Core Facility operates 14 different instruments in various performance classes and application areas.

We cover the full range from the classic 3-laser 8-color analyzer to the most sophisticated 7-laser spectral analyzer and image cytometer to the image-enabled spectral cell sorter BD FACSDiscover™ S8.

Learn more

Services

The Flow Cytometry Core Facility provides a range of services to our users:

Cell sorting: Separation of specific cell populations for further analysis or experimentation. Cell sorting is provided as a full service with an operator. This cell sorting service is limited to standard office hours. Alternatively, advanced users can learn how to operate the Sony MA900™cell sorter.

Learn more

Teaching

The Flow Cytometry Core Facility offers individual training courses on our analyzers and the Sony MA900™cell sorter as well as regular workshops to introduce you to flow cytometry, cell sorting or spectral flow cytometry in general or the basics of data analysis.

Dates for regular online trainings can be found at the event section of the BTC homepage.

Learn more

Do you have any questions?

FAQs

Answers to frequently asked questions about the PPMS booking system, the billing of core facility services and much more can be found in our General FAQ section and specific sorting related Questions can be found under Sorter FAQs.

General FAQs

Sorter FAQs

Consulting

Are you interested in our services? Please get in touch with the relevant contact person or send us an e-mail: fccf@uni-bonn.de

Contact

Acknowledgement

You would like to publish your results but do not know how to take the support of the Core Facility into account? Here you will find detailed instructions.

Further information about acknowledgements

Needful Links

Online-Scheduling

BTC-Cloud

Bonn Technology Campus

Registration

internal research funding

Email List Subscription

FluoroFinder (Panel Design, Spectrum Viewer and more)

German Society for Cytometry (DGfZ)

International Society for Advancement of Cytometry

Events

Tuesday Sep 09, 2025 until Sep 12, 2025

Annual Meeting of the German Society of Flow Cytometry2025

CRTD, Center for ...

Whole Day

With the theme “From Flow Cytometrist for Flow Cytometrist”, this year’s meeting is centered on fostering an atmosphere of technological exchange and knowledge ...

Friday Jul 25, 2025

“Autofluorescence in Spectral Cytometry”.

Online via Microsoft ...

01:00 PM - 03:30 PM

Topics to be covered: What is autofluorescence (AF)? Primary sources of cellular autofluorescence What is needed to identify AF? AF ...

Wednesday Jul 09, 2025

“A New View on Cells – Real -Time Imaging with BD CellView™”

Lehrgebäude (Haus A10),– ...

01:00 PM - 03:00 PM

📅 July 9, 2025 📍 Lehrgebäude (Haus A10), Raum 010.1.01 – University Clinic Bonn 🕐 13:00 – 15:00, followed by snacks and networking We know that many of ...

Tuesday Jul 22, 2025

Spectral Flow Cytometry Seminar July 22nd, 2025

zoom

03:00 PM - 05:00 PM

Introduction to Spectral Flow Cytometry Differences between Conventional and Spectral Flow Cytometry Unmixing vs Compensation Enhanced Sensitivity Data ...

13137

hours booked (12 month)

307

active users, 85 different groups

instruments (4 cell sorters, 10 analysers)

News from the Core Facility / Science news

Reducing Neuroinflammation Could Help Fight Alzheimer’s

Alzheimer’s disease is the most common cause of dementia. A promising approach for its treatment is the prevention of inflammatory processes in the brain. An international team of scientists around Dr. Róisín McManus, Prof. Eicke Latz and Prof. Michael Heneka now provide new evidence supporting this approach and potentially contributing to the development of more effective therapies. The results have now been published in the journal “Immunity”.

How obesity also affects the next generation

Children born to obese mothers are at higher risk of developing metabolic disorders, even if they follow a healthy diet themselves. A new study from the University of Bonn offers an explanation for this phenomenon. In obese mice, certain cells in the embryo’s liver are reprogrammed during pregnancy. This leads to long-term changes in the offspring’s metabolism. The researchers believe that these findings could also be relevant for humans. The study has now been published in the journal Nature.

New way to prevent duodenal cancer

People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn have now discovered a mechanism in the local immune system that can drive the development of cancer. They see this as a promising new approach to preventing duodenal carcinoma in people with FAP. The results have now been published in the journal "Nature Communications".

Bonn researchers use nanobodies to elucidate pore formation by gasdermin D in cell membranes

Bonn researchers use nanobodies to elucidate pore formation by gasdermin D in cell membranesThe formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine to form large pores in the cell membrane, which allow the release of inflammatory messengers. As methods for studying these processes in living cells have so far been inadequate, the sequence of oligomerization, pore formation and membrane incorporation has remained unclear. An international research team led by the University Hospital Bonn (UKB) and the University of Bonn has succeeded in answering this question with the help of antibody fragments, so-called nanobodies, which they have identified. They hope that this will lead to potential therapeutic applications. Their results have now been published in the journal “Nature Communications”.

News archive

Publications

2025

Acknowledgements:

1. Breßer, Mona; Siemens, Kevin D.; Schneider, Linda; Lunnebach, Jonah E.; Leven, Patrick; Glowka, Tim R. et al. (2025): Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation. In: EMBO molecular medicine 17 (2), S. 301–335. DOI: 10.1038/s44321-024-00189-w .

2. Eichhorn, Lars; Kleiner, Jan Lukas; Bartsch, Benedikt; Nazir, Mariam Louis Fathy; Zhang, Yunyang; Coburn, Mark et al. (2025): CCR2 dependent recruited pro-inflammatory monocytes contribute to the development of left ventricular hypertrophy in mice upon transverse aortic constriction. In: PloS one 20 (4), e0318407. DOI: 10.1371/journal.pone.0318407 .

3. Gohr, Florian N.; Christensen, Maria H.; Jenster, Lea-Marie; Tesfamariam, Yonas M.; Lapp, Dorothee J.; Mackenzie, Jason; Schmidt, Florian I. (2025): A novel reporter to visualize and quantify endogenous inflammasomes and caspase-1 recruitment.

4. Hansen, Aylin; Sanders, Christine; Fronhoffs, Florian; Funke, Kai; Kristiansen, Glen; Schorle, Hubert (2025): BRD9 inhibition as potential treatment option for testicular germ cell tumors. In: Andrology. DOI: 10.1111/andr.70038 .

5. Kaiser, Kim M.; Raabe, Jan; ToVinh, Michael; Hack, Gudrun; Ahmad, Sarah; Müller, Niko et al. (2025): IL-17A-producing NKp44(-) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue. In: 2041-1723 16 (1), S. 3873. DOI: 10.1038/s41467-025-58907-y .

6. Kirchhoff, Alexander; Herzner, Anna-Maria; Urban, Christian; Piras, Antonio; Düster, Robert; Mahlberg, Julia et al. (2025): RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I. In: The EMBO Journal 44 (3), S. 824–853. DOI: 10.1038/s44318-024-00331-x .

7. Koch, Philipp; Zhang, Zijian; Genuth, Naomi R.; Susanto, Teodorus Theo; Haimann, Martin; Khmelinskaia, Alena et al. (2025): A versatile toolbox for determining IRES activity in cells and embryonic tissues. In: The EMBO Journal 44 (9), S. 2695–2724. DOI: 10.1038/s44318-025-00404-5 .

8. Mohamed, Adham Abuelola; Wallerath, Christina; Hunkler, Charlotte; Hartmann, Gunther; Stankovic, Sanda; Brooks, Andrew G.; Schlee, Martin (2025): RIG-I Stimulation Enhances Effector Function and Proliferation of Primary Human CD8 T Cells.

2024

Co-Authorship:

1. Silva Ribeiro, Dalila Juliana; Yüksel, Seniz; Dolf, Andreas; Wachten, Dagmar (2024): Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue. In Methods in molecular biology (Clifton, N.J.) 2713, pp. 149–158. DOI: 10.1007/978-1-0716-3437-0_10 .

Acknowledgements:

1. Böhner, Alexander M. C.; Effland, Alexander; Jacob, Alice M.; Böhner, Karin A. M.; Abdullah, Zeinab; Brähler, Sebastian et al. (2024): Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by a 3-dimensional fast marching algorithm. In: Kidney international 105 (6), S. 1254–1262. DOI: 10.1016/j.kint.2024.01.043 .

2. Colón, David F.; Wanderley, Carlos W.; Turato, Walter M.; Borges, Vanessa F.; Franchin, Marcelo; Castanheira, Fernanda V. S. et al. (2024): Paediatric sepsis survivors are resistant to sepsis-induced long-term immune dysfunction. In: British journal of pharmacology 181 (8), S. 1308–1323. DOI: 10.1111/bph.16286 .

3. Frasconi, Teresa M.; Kurts, Christian; Dhana, Ermanila; Kaiser, Romina; Reichelt, Miriam; Lukacs-Kornek, Veronika et al. (2024): Renal IL-23-Dependent Type 3 Innate Lymphoid Cells Link Crystal-induced Intrarenal Inflammasome Activation with Kidney Fibrosis. In: Journal of immunology (Baltimore, Md. : 1950) 213 (6), S. 865–875. DOI: 10.4049/jimmunol.2400041 .

4. Guth, Cécile; Schumacher, Pia Philippa; Vijayakumar, Archena; Borgmann, Hannah; Balles, Helene; Koschel, Marianne et al. (2024): Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response. In: Journal of Innate Immunity 16 (1), S. 159–172. DOI: 10.1159/000536357 .

5. Hardt, Miriam; Mayr, Alexandra; Kutschera, Eric; Marciniak, Jana; Küchler, Erika Calvano; Kirschneck, Christian et al. (2024): Rho Kinases and Reactive Oxygen Species in Autophagy Regulation by Pressure in Periodontal Ligament Cells. In: Braz. Dent. J. 35, Artikel e24-5944. DOI: 10.1590/0103-6440202405944 .

6. Hawwari, Ibrahim; Rossnagel, Lukas; Rosero, Nathalia; Maasewerd, Salie; Vasconcelos, Matilde B.; Jentzsch, Marius et al. (2024): Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes. In: EMBO molecular medicine 16 (8), S. 1901–1929. DOI: 10.1038/s44321-024-00093-3 .

7. Heine, Annkristin; Lemmermann, Niels A. W.; Flores, Chrystel; Becker-Gotot, Janine; Garbi, Natalio; Brossart, Peter; Kurts, Christian (2024): Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination. In: Frontiers in immunology 15, S. 1338499. DOI: 10.3389/fimmu.2024.1338499 .

8. Heuser-Loy, Christoph; Baumgart, Ann-Kathrin; Hackstein, Carl-Philipp; Courrèges, Christina J. F.; Philipp, Marie-Sophie; Thaiss, Christoph A. et al. (2024): Conditional NKT Cell Depletion in Mice Reveals a Negative Feedback Loop That Regulates CTL Cross-Priming. In: Journal of immunology (Baltimore, Md. : 1950) 212 (1), S. 35–42. DOI: 10.4049/jimmunol.2300662 .

9. Kirchhoff, Alexander; Herzner, Anna-Maria; Urban, Christian; Piras, Antonio; Düster, Robert; Mahlberg, Julia et al. (2024): RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I. In: The EMBO Journal. DOI: 10.1038/s44318-024-00331-x .

10. Luca, Domnica; Lee, Sumin; Hirota, Keiji; Okabe, Yasutaka; Uehori, Junji; Izawa, Kazushi et al. (2024): Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity. In: Science Advances 10 (9), eadk0820. DOI: 10.1126/sciadv.adk0820 .

11. Ossendorff, Robert; Wang, Su; Kurth, Sarah; Jaenisch, Max; Assaf, Elio; Strauss, Andreas C. et al. (2024): TNFα-Induced Inflammation Model-Evaluation of Concentration and Passage-Dependent Effects on Bovine Chondrocytes. In: International Journal of Molecular Sciences 25 (17). DOI: 10.3390/ijms25179136 .

12. Rodrigo, Maria Belen; Min, Anna de; Jorch, Selina Kathleen; Martin-Higueras, Cristina; Baumgart, Ann-Kathrin; Goldyn, Beata et al. (2024): Dual fluorescence reporter mice for Ccl3 transcription, translation, and intercellular communication. In: The Journal of experimental medicine 221 (7). DOI: 10.1084/jem.20231814 .

13. Rottmann, Sophia; Lukacs-Kornek, Veronika (2024): Isolation, Purification, and Comprehensive Flow Cytometry Assessment of Lung Stromal Cells. In: Current protocols 4 (12), e70078. DOI: 10.1002/cpz1.70078 .

14. Schiffelers, Lisa D. J.; Tesfamariam, Yonas M.; Jenster, Lea-Marie; Diehl, Stefan; Binder, Sophie C.; Normann, Sabine et al. (2024): Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application. In: Nat Commun 15 (1), S. 8266. DOI: 10.1038/s41467-024-52110-1 .

15. Schmidt, Elena N. C.; Evert, Bernd O.; Pregler, Barbara E. F.; Melhem, Ahmad; Hsieh, Meng-Chun; Raspe, Markus et al. (2024): Tonabersat enhances temozolomide-mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition. In: Molecular Oncology. DOI: 10.1002/1878-0261.13786 .

16. Sieckmann, Katharina; Winnerling, Nora; Silva Ribeiro, Dalila Juliana; Kardinal, Ronja; Steinheuer, Lisa Maria; Schermann, Geza et al. (2024): BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue.

17. Silva Ribeiro, Dalila Juliana; Yüksel, Seniz; Dolf, Andreas; Wachten, Dagmar (2024): Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue. In: Methods in molecular biology (Clifton, N.J.) 2713, S. 149–158. DOI: 10.1007/978-1-0716-3437-0_10.

18. Surendar, Jayagopi; Hackenberg, Roslind K.; Schmitt-Sánchez, Fabio; Ossendorff, Robert; Welle, Kristian; Stoffel-Wagner, Birgit et al. (2024): Osteomyelitis is associated with increased anti-inflammatory response and immune exhaustion. In: Frontiers in immunology 15, S. 1396592. DOI: 10.3389/fimmu.2024.1396592 .

19. van Baarle, Lies; Simone, Veronica de; Schneider, Linda; Santhosh, Sneha; Abdurahiman, Saeed; Biscu, Francesca et al. (2024): IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer. In: Nat Commun 15 (1), S. 6079. DOI: 10.1038/s41467-024-50438-2 .

20. Weiss, Felix D.; Alvarez, Yubell; Shakeri, Farhad; Sahu, Anshupa; Leka, Petro; Dernst, Alesja et al. (2024): Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice. In: Cell death and differentiation 31 (12), S. 1717–1729. DOI: 10.1038/s41418-024-01379-2 .

21. Xiao, Hongkui; Ulmert, Isabel; Bach, Luisa; Huber, Johanna; Narasimhan, Hamsa; Kurochkin, Ilia et al. (2024): Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses. In: Nat Commun 15 (1), S. 3554. DOI: 10.1038/s41467-024-46966-6 .

22. Mangan, Matthew S. J.; Akbal, Anil; Rivara, Sophie; Schröder, Agnes; Horvath, Gabor; Walch, Philipp et al.: Cytosolic sodium accumulation is a common danger signal triggering endocytic dysfunction and NLRP3 inflammasome activation: bioRxiv. Online verfügbar unter https://www.biorxiv.org/content/10.1101/2024.03.26.586774v2, zuletzt geprüft am 22.11.2024.

23. Marques Palma, Luisa; Schlaweck, Sebastian; Flores, Chrystel; Aslan, Hasan; Brossart, Peter; Kurts, Christian et al.: Chemokine Dynamics after Mrna Vaccination: Social Science Research Network (4914051), zuletzt geprüft am 22.11.2024.

24. Messmer, Julia M.; Thommek, Calvin; Piechutta, Manuel; Venkataramani, Varun; Wehner, Rebekka; Westphal, Dana et al.: T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels. In: 1074-7613 57 (11), 2688‐2703.e11. DOI: 10.1016/j.immuni.2024.09.003 .

25. Oberkircher, Lara M.; Scheiding, Victoria M.; Rafeld, H. Linda; Hanssen, Eric; Hansen, Jan N.; Fleischmann, Markus J. et al.: Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice. In: 1933-0219 17 (5), S. 777–792. DOI: 10.1016/j.mucimm.2024.05.001 .

26. Salzmann, Rebekka J. S.; Krötz, Christina; Mocan, Tudor; Mocan, Lavinia P.; Grapa, Cristiana; Rottmann, Sophia et al.: Increased type-I interferon level is associated with liver damage and fibrosis in primary sclerosing cholangitis. In: 2471-254X 8 (3), e0380. DOI: 10.1097/HC9.0000000000000380 .

27. Schiffer, Miriam; Wagner, Kevin; Carls, Esther; Nicke, Julia; Hesse, Michael; Fratila, Raluca Maria et al.: Nanoparticle Assisted Targeting of Heart Lesions with Cardiac Myofibroblasts: Combined Gene and Cell Therapy: Social Science Research Network (4786591), zuletzt geprüft am 22.11.2024.

28. Theodorou, Maria Rafailia; Yu, Jiangyan; Nikolka, Fabian; Zurkovic, Jelena; Wientjens, Chantal; Weiss, Patricia et al.: Anabolic lipid metabolism regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health: bioRxiv. Online verfügbar unter https://www.biorxiv.org/content/10.1101/2024.03.26.586766v1, zuletzt geprüft am 22.11.2024.

29. Wurnig, Silas L.; Huber, Max E.; Weiler, Corinna; Baltrukevich, Hanna; Merten, Nicole; Stötzel, Isabel et al.: A fluorescent probe enables the discovery of improved antagonists targeting the intracellular allosteric site of the chemokine receptor CCR7: bioRxiv. Online verfügbar unter https://www.biorxiv.org/content/10.1101/2024.08.27.607356v1, zuletzt geprüft am 22.11.2024.

2023

Co-Authorship:

1. Liter Silva Ribeiro, D.J., Yüksel, S., Dolf, A., and Wachten, D. (2024). Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue. In Tissue-Resident Macrophages: Methods and Protocols Methods in Molecular Biology., E. Mass, ed. (Springer US), pp. 149–158. 10.1007/978-1-0716-3437-0_10 .

Acknowledgements:

1. Funke, Kai; Einsfelder, Ulf; Hansen, Aylin; Arévalo, Lena; Schneider, Simon; Nettersheim, Daniel et al. (2023): Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours. In: British journal of cancer 128 (12), S. 2270–2282. DOI: 10.1038/s41416-023-02247-5 .

2. Hackstein, Carl-Philipp; Spitzer, Jasper; Symeonidis, Konstantinos; Horvatic, Helena; Bedke, Tanja; Steglich, Babett et al. (2023): Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. In: Journal of hepatology 79 (1), S. 150–166. DOI: 10.1016/j.jhep.2023.02.026 .

3. Jenster, Lea-Marie; Lange, Karl-Elmar; Normann, Sabine; vom Hemdt, Anja; Wuerth, Jennifer D.; Schiffelers, Lisa D. J. et al. (2023): P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. In: The Journal of experimental medicine 220 (1). DOI: 10.1084/jem.20220837 .

4. Klümper, Niklas; Ralser, Damian J.; Ellinger, Jörg; Roghmann, Florian; Albrecht, Julia; Below, Eduard et al. (2023): Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance. In: Clinical cancer research : an official journal of the American Association for Cancer Research 29 (8), S. 1496–1505. DOI: 10.1158/1078-0432.CCR-22-1764 .

5. Raabe, Jan; Kaiser, Kim M.; ToVinh, Michael; Finnemann, Claudia; Lutz, Philipp; Hoffmeister, Christoph et al. (2023): Identification and characterization of a hepatic IL-13-producing ILC3-like population potentially involved in liver fibrosis. In: Hepatology (Baltimore, Md.) 78 (3), S. 787–802. DOI: 10.1097/HEP.0000000000000350 .

6. Regt, Ann Kristin de; Anand, Kanchan; Ciupka, Katrin; Bender, Felix; Gatterdam, Karl; Putschli, Bastian et al. (2023): A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA. In: Nucleic acids research 51 (21), S. 11893–11910. DOI: 10.1093/nar/gkad835 .

7. Tsukamoto, Yuta; Hiono, Takahiro; Yamada, Shintaro; Matsuno, Keita; Faist, Aileen; Claff, Tobias et al. (2023): Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. In: Science (New York, N.Y.) 379 (6632), S. 586–591. DOI: 10.1126/science.add0875 .

8. Tzaridis, Theophilos; Weller, Johannes; Bachurski, Daniel; Shakeri, Farhad; Schaub, Christina; Hau, Peter et al. (2023): A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression. In: International journal of cancer 152 (2), S. 308–319. DOI: 10.1002/ijc.34261 .

9. Colón, David F.; Wanderley, Carlos W.; Turato, Walter M.; Borges, Vanessa F.; Franchin, Marcelo; Castanheira, Fernanda V. S. et al.: Paediatric sepsis survivors are resistant to sepsis-induced long-term immune dysfunction. In: 1476-5381 181 (8), S. 1308–1323. DOI: 10.1111/bph.16286 .

10. Frasconi, Teresa M.; Kurts, Christian; Dhana, Ermanila; Kaiser, Romina; Reichelt, Miriam; Lukacs-Kornek, Veronika et al.: Renal IL-23–Dependent Type 3 Innate Lymphoid Cells Link Crystal-induced Intrarenal Inflammasome Activation with Kidney Fibrosis. In: 0022-1767 213 (6), S. 865–875. DOI: 10.4049/jimmunol.2400041 .

11. Heuser-Loy, Christoph; Baumgart, Ann-Kathrin; Hackstein, Carl-Philipp; Courrèges, Christina J. F.; Philipp, Marie-Sophie; Thaiss, Christoph A. et al.: Conditional NKT Cell Depletion in Mice Reveals a Negative Feedback Loop That Regulates CTL Cross-Priming. In: 0022-1767 212 (1), S. 35–42. DOI: 10.4049/jimmunol.2300662 .

2022

Co-Authorship:

1. Steinhoff, C., Pickarski, N., Litt, T., Hajdas, I., Welte, C., Wurst, P., Kühne, D., Dolf, A., Germer, M., and Kallmeyer, J. (2022). NEW APPROACH TO SEPARATE AND DATE SMALL SPORES AND POLLEN FROM LAKE SEDIMENTS IN SEMI-ARID CLIMATES. Radiocarbon 64, 1191–1207. 10.1017/RDC.2022.34.

Acknowledgements:

1. Arévalo, Lena; Merges, Gina Esther; Schneider, Simon; Oben, Franka Enow; Neumann, Isabelle Sophie; Schorle, Hubert (2022): Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice. In: PLoS Genet 18 (6), e1010272. DOI: 10.1371/journal.pgen.1010272.

2. Braegelmann, C.; Niebel, D.; Ferring-Schmitt, S.; Fetter, T.; Landsberg, J.; Hölzel, M. et al. (2022): Epigallocatechin-3-gallate exhibits anti-inflammatory effects in a human interface dermatitis model-implications for therapy. In: Journal of the European Academy of Dermatology and Venereology : JEADV 36 (1), S. 144–153. DOI: 10.1111/jdv.17710.

3. Esser, Laura Kristin; Branchi, Vittorio; Shakeri, Farhad; Simon, Adrian Georg; Stephan, Carsten; Kristiansen, Glen et al. (2022): Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels. In: International journal of oncology 60 (2). DOI: 10.3892/ijo.2022.5310.

4. Funke, Kai; Düster, Robert; Wilson, Prince De-Graft; Arévalo, Lena; Geyer, Matthias; Schorle, Hubert (2022): Transcriptional CDK Inhibitors as Potential Treatment Option for Testicular Germ Cell Tumors. In: Cancers 14 (7). DOI: 10.3390/cancers14071690.

5. Hauke, Jan; Harter, Philipp; Ernst, Corinna; Burges, Alexander; Schmidt, Sandra; Reuss, Alexander et al. (2022): Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883). In: Journal of Medical Genetics 59 (3), S. 248–252. DOI: 10.1136/jmedgenet-2020-107353.

6. Karagiannis, Fotios; Peukert, Konrad; Surace, Laura; Michla, Marcel; Nikolka, Fabian; Fox, Mario et al. (2022): Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. In: Nature 609 (7928), S. 801–807. DOI: 10.1038/s41586-022-05128-8.

7. Leven, Patrick; Schneider, Reiner; Siemens, Kevin D.; Jackson, Walker S.; Wehner, Sven (2022): Application of a RiboTag-based approach to generate and analyze mRNA from enteric neural cells. In: Neurogastroenterology and motility 34 (7), e14309. DOI: 10.1111/nmo.14309.

8. Mallesh, Shilpashree; Hove, Anne S. ten; Schneider, Reiner; Schneiker, Bianca; Efferz, Patrik; Kalff, Jörg C. et al. (2022): Sympathetic Innervation Modulates Mucosal Immune Homeostasis and Epithelial Host Defense. In: Cells 11 (16). DOI: 10.3390/cells11162606.

9. Merges, Gina Esther; Meier, Julia; Schneider, Simon; Kruse, Alexander; Fröbius, Andreas Christian; Kirfel, Gregor et al. (2022): Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice. In: Development (Cambridge, England) 149 (12). DOI: 10.1242/dev.200330.

10. Niemann, Birte; Haufs-Brusberg, Saskia; Puetz, Laura; Feickert, Martin; Jaeckstein, Michelle Y.; Hoffmann, Anne et al. (2022): Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. In: Nature 609 (7926), S. 361–368. DOI: 10.1038/s41586-022-05041-0.

11. Schneider, Reiner; Leven, Patrick; Mallesh, Shilpashree; Breßer, Mona; Schneider, Linda; Mazzotta, Elvio et al. (2022): IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function. In: Commun Biol 5 (1), S. 811. DOI: 10.1038/s42003-022-03772-4.

12. Vennin, Constance; Hewel, Charlotte; Todorov, Hristo; Wendelmuth, Marlon; Radyushkin, Konstantin; Heimbach, André et al. (2022): A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice. In: Cells 11 (21). DOI: 10.3390/cells11213405.

13. Zietzer, Andreas; Breitrück, Nils; Düsing, Philip; Böhle, Sabrina; Klussmann, Jens Peter; Al-Kassou, Baravan et al. (2022): The lncRNA MRPL20-AS1 is associated with severe OSAS and downregulated upon hypoxic injury of endothelial cells. In: International journal of cardiology 369, S. 65–68. DOI: 10.1016/j.ijcard.2022.08.035.

14. Zillich, Lea; Poisel, Eric; Frank, Josef; Foo, Jerome C.; Friske, Marion M.; Streit, Fabian et al. (2022): Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum. In: Translational Psychiatry 12 (1), S. 190. DOI: 10.1038/s41398-022-01959-1.