DNA sequencing services
Find information on our DNA-based sequencing services below.
You have a sequencing project? Read here how to use our services.
Whole genome sequencing (WGS)
enables the comprehensive analysis of an organism’s entire genetic material. By capturing both coding and non-coding regions of the genome, WGS allows for the detection of single nucleotide variants, structural variations, and copy number changes at high resolution. Our NGS Core Facility provides end-to-end WGS services, including library preparation, short- or long-read sequencing and data processing and basic QC.
Whole exome sequencing (WES)
focuses on the analysis of all protein-coding regions of the genome, known as exons, which represent approximately 1–2% of the genome but harbor the majority of known disease-related variants. WES enables efficient detection of single nucleotide variants and small insertions or deletions within coding regions, making it a cost-effective alternative to WGS for many applications. Our NGS Core Facility offers comprehensive WES services, including library preparation, high-quality short-read sequencing, data processing, and basic quality control.
Targeted sequencing
enables high-resolution analysis of specific genes, genomic regions, or variant hotspots of interest. By enriching selected regions of the genome, this approach offers deep coverage and high sensitivity, making it ideal for detecting low-frequency variants and studying known disease-associated loci. We are happy to support the planning of your target enrichment strategy and offer library preparation and sequencing services based on your custom amplicons.
Epigenetics
DNA methylation, particularly at CpG sites, plays a vital role in regulating gene expression, maintaining cellular identity, and driving disease development.
Our NGS Core Facility provides comprehensive, cutting-edge solutions for genome-wide DNA methylation analysis. These services are designed for researchers aiming to uncover epigenetic mechanisms in development, disease, and environmental response.
Our epigenetics service portfolio includes:
- Genome-wide Enzymatic Methyl-Seq (EMSeq) – a gentle, bisulfite-free method for accurate methylation detection
- Targeted methylation sequencing using the TWIST Methylome Panel – focused profiling of functionally relevant regions
- BioModal evoC 6-letter sequencing – simultaneous detection of methylation and genetic variation in a single workflow
- Long-read direct DNA sequencing – enabling native methylation detection and analysis of base modifications
All services include high-quality sample preparation, sequencing, and basic data processing. Custom solutions and bioinformatics support are available upon request.
ChIP-Seq
Chromatin Immunoprecipitation followed by sequencing (ChIP-Seq) is a powerful method to identify genome-wide binding sites of DNA-associated proteins, such as transcription factors or histone modifications. It provides valuable insights into gene regulation and chromatin structure. We offer ChIP-Seq library preparation and sequencing services, along with consultation on experimental design and input material requirements.
ATAC-Seq
ATAC-Seq (Assay for Transposase-Accessible Chromatin using sequencing) is a sensitive technique to profile genome-wide chromatin accessibility. It enables the identification of open regulatory regions and provides information on the epigenetic landscape of cells. Our facility supports ATAC-Seq workflows from library preparation through sequencing.Metagenomics
Metagenomic sequencing enables the comprehensive analysis of complex microbial communities by directly sequencing DNA from environmental or host-associated samples. It allows taxonomic profiling, functional analysis, and discovery of novel organisms without the need for cultivation. Our Core Facility offers end-to-end metagenomics solutions, including- sample collection & DNA extraction guidance
- library preparation & sequencing for 16S/18S/ITS targeted and shotgun metagenomics
- metatranscriptomics
The Core Facilities thank the German Research Foundation for continuous support.
