Next Generation Sequencing Core Facility

The Next Generation Sequencing (NGS) Core Facility offers rapid, high-throughput sequencing services. We provide the research community with access to state-of-the-art sequencing technologies for cutting-edge omics research. In addition to serving the local research community, the NGS Core Facility is part of the West German Genome Center (WGGC) and a member of the national NGS Competence Network (NGS-CN).

Services

Getting started

Costs

Publications

Contact / Sample submission

Services

Find out about our wide range of NGS-based services, from genomics to epigenetics, proteomics and single-cell applications.

Learn more

Team

Meet our NGS Core Facility team. We are dedicated to supporting you with your sequencing projects.

Learn more

Instrumentation

Take a look at our selection of sequencers, single-cell analysis systems and laboratory automation.

Learn more

Do you have any questions?

FAQ

Find answers to frequently asked questions about our NGS Core Facility services, sample submission, data transfer, and more in our FAQ section

Consulting

Are you interested in our services or need support planning your sequencing experiments? We are happy to help!

Please e-mail us at NGS-Core@uni-bonn.de

Acknowledgement

Are you planning to publish the results of your NGS experiment but unsure how to properly acknowledge the support of the Core Facility? Find detailed guidelines here.

Additional Resources

Internal research funding

DFG funding opportunities

Bonn Technology Campus

West German Genome Center

German NGS Competence Network

>50,000

samples sequenced and counting!

>600 Tb

of sequencing data generated - enough to fill ~150,000 HD movies

>250

annual sample submissions from users across 90 research groups & 40 institutes

News from the Core Facility / Science news

Large genetic study on severe COVID-19

Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women. In addition, they were able to show that genetic changes in three other genes of the innate immune system contribute to severe COVID-19. The results have now been published in the journal “Human Genetics and Genomics Advances”.

New findings on hair loss in men

A receding hairline, a total loss of hair from the crown, and ultimately, the classical horseshoe-shaped pattern of baldness: Previous research into male pattern hair loss, also termed androgenetic alopecia, has implicated multiple common genetic variants. Human geneticists from the University Hospital of Bonn (UKB) and by the Transdisciplinary Research Unit “Life & Health” of the University of Bonn have now performed a systematic investigation of the extent to which rare genetic variants may also contribute to this disorder. For this purpose, they analyzed the genetic sequences of 72,469 male participants from the UK Biobank project. The analyses identified five significantly associated genes, and further corroborated genes implicated in previous research. The results have now been published in the prestigious scientific journal Nature Communications.

Publications

2025

Breßer, Mona; Siemens, Kevin D.; Schneider, Linda; Lunnebach, Jonah E.; Leven, Patrick; Glowka, Tim R. et al. (2025): Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation. In: EMBO molecular medicine 17 (2), S. 301–335. DOI: 10.1038/s44321-024-00189-w.

Kirchhoff, Alexander; Herzner, Anna-Maria; Urban, Christian; Piras, Antonio; Düster, Robert; Mahlberg, Julia et al. (2025): RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I. In: The EMBO Journal 44 (3), S. 824–853. DOI: 10.1038/s44318-024-00331-x.

Kraege, Anton; Chavarro-Carrero, Edgar; Schnell, Eva; Heilmann-Heimbach, Stefanie; Becker, Kerstin; Köhrer, Karl et al. (2025): High quality genome assembly and annotation (v1) of the eukaryotic freshwater microalga Coccomyxa elongata SAG 216-3b. In: G3 (Bethesda, Md.) 15 (2). DOI: 10.1093/g3journal/jkae294.

Zech, Michael; Dzinovic, Ivana; Skorvanek, Matej; Harrer, Philip; Necpal, Jan; Kopajtich, Robert et al. (2025): Combined genomics and proteomics unveils elusive variants and vast aetiologic heterogeneity in dystonia. In: Brain : a journal of neurology. DOI: 10.1093/brain/awaf059.

2024

Abdallah, Ali T.; Konermann, Anna (2024): Unraveling Divergent Transcriptomic Profiles: A Comparative Single-Cell RNA Sequencing Study of Epithelium, Gingiva, and Periodontal Ligament Tissues. In: International Journal of Molecular Sciences 25 (11). DOI: 10.3390/ijms25115617.

Abdallah, Ali T.; Peitz, Michael; Konermann, Anna (2024): Revealing Genetic Dynamics: scRNA-seq Unravels Modifications in Human PDL Cells across In Vivo and In Vitro Environments. In: International Journal of Molecular Sciences 25 (9), S. 4731. DOI: 10.3390/ijms25094731.

Abdelrazek, Ibrahim M.; Knaus, Alexej; Javanmardi, Behnam; Krawitz, Peter M.; Horn, Denise; Abdalla, Ebtesam M.; Kumar, Sheetal (2024): Acromesomelic Dysplasia With Homozygosity for a Likely Pathogenic BMPR1B Variant: Postaxial Polydactyly as a Novel Clinical Finding. In: Molecular genetics & genomic medicine 12 (10), e70023. DOI: 10.1002/mgg3.70023.

Arlt, Annabelle; Knaus, Alexej; Hsieh, Tzung-Chien; Klinkhammer, Hannah; Bhasin, Meghna Ahuja; Hustinx, Alexander et al. (2024): Next-generation phenotyping in Nigerian children with Cornelia de Lange syndrome. In: American journal of medical genetics. Part A 194 (9), e63641. DOI: 10.1002/ajmg.a.63641.

Bohleber, Simon; Fradejas-Villar, Noelia; Zhao, Wenchao; Reuter, Uschi; Schweizer, Ulrich (2022): High-Resolution Ribosome Profiling Reveals Gene-Specific Details of UGA Re-Coding in Selenoprotein Biosynthesis. In: Biomolecules 12 (10). DOI: 10.3390/biom12101504.

Both, Annika; Ibrahim, Ghosn; Marciniak, Jana; Rath-Deschner, Birgit; Küchler, Erika Calvano; Kirschneck, Christian et al. (2024): Bone, dentin and cementum differentially influence the differentiation of osteoclast-like cells.

Claus, I.; Sivalingam, S.; Koller, A. C.; Weiß, A.; Mathey, C. M.; Sindermann, L. et al. (2024): Contribution of Rare and Potentially Functionally Relevant Sequence Variants in Schizophrenia Risk-Locus Xq28,distal. In: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, e33011. DOI: 10.1002/ajmg.b.33011.

Fabiano, Marietta; Oikawa, Naoto; Kerksiek, Anja; Furukawa, Jun-ichi; Yagi, Hirokazu; Kato, Koichi et al. (2024): Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function. In: International Journal of Molecular Sciences 25 (10), S. 5417. DOI: 10.3390/ijms25105417.

Grünhofer, Paul; Heimerich, Ines; Pohl, Svenja; Oertel, Marlene; Meng, Hongjun; Zi, Lin et al. (2024): Suberin deficiency and its effect on the transport physiology of young poplar roots. In: The New phytologist 242 (1), S. 137–153. DOI: 10.1111/nph.19588.

Henne, Sabrina K.; Hochfeld, Lara M.; Bartmann, Werner; Welss, Thomas; Nöthen, Markus M.; Heilmann-Heimbach, Stefanie (2024): Molecular monitoring of short- and long-term transcriptional effects of hair growth stimulating agents. In: PloS one 19 (12), e0316128. DOI: 10.1371/journal.pone.0316128.

Henne, Sabrina K.; Nöthen, Markus M.; Heilmann-Heimbach, Stefanie (2024): Männlicher Haarausfall – was uns unsere Gene verraten. In: Biospektrum 30 (1), S. 37–40. DOI: 10.1007/s12268-024-2082-4.

Ishorst, Nina; Hölzel, Selina; Greve, Carola; Yilmaz, Öznur; Lindenberg, Tobias; Lambertz, Jessica et al. (2024): Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models. In: European journal of human genetics : EJHG. DOI: 10.1038/s41431-024-01775-9.

Jaeschke, Andrea; May, S. Matthias; Hakobyan, Anna; Mörchen, Ramona; Bubenzer, Olaf; Bernasconi, Stefano M. et al. (2024): Microbial hotspots in a relict fog-dependent Tillandsia landbeckii dune from the coastal Atacama Desert. In: Global and Planetary Change 234, S. 104383. DOI: 10.1016/j.gloplacha.2024.104383.

Kirchhoff, Alexander; Herzner, Anna-Maria; Urban, Christian; Piras, Antonio; Düster, Robert; Mahlberg, Julia et al. (2024): RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I. In: The EMBO Journal. DOI: 10.1038/s44318-024-00331-x.

Klümper, Niklas; Tran, Ngoc Khanh; Zschäbitz, Stefanie; Hahn, Oliver; Büttner, Thomas; Roghmann, Florian et al. (2024): NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer. In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (20), S. 2446–2455. DOI: 10.1200/JCO.23.01983.

Laura Gesine Stüssel: MicroRNA-149 ist assoziiert mit der Bildung von orofazialen Spalten und veränderter Neuralleistenzell-Migration.

Scheiblich, Hannah; Eikens, Frederik; Wischhof, Lena; Opitz, Sabine; Jüngling, Kay; Cserép, Csaba et al.: Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. In: 0896-6273 112 (18), 3106‐3125.e8. DOI: 10.1016/j.neuron.2024.06.029.

Scheiblich, Hannah; Eikens, Frederik; Wischhof, Lena; Opitz, Sabine; Jüngling, Kay; Cserép, Csaba et al. (2024): Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. In: Neuron 112 (18), 3106-3125.e8. DOI: 10.1016/j.neuron.2024.06.029.

Schneider, Linda; Schneider, Reiner; Hamza, Ebrahim; Wehner, Sven (2024): Extracellular matrix substrates differentially influence enteric glial cell homeostasis and immune reactivity. In: Frontiers in immunology 15, S. 1401751. DOI: 10.3389/fimmu.2024.1401751.

Sengul, Hilal; Bantavi, Vasiliki; Yim, Andrew Y.F. Li; Efferz, Patrik; Schneiker, Bianca; Jonge, Wouter J. de; Wehner, Sven (2024): Layer-specific Transcriptional Signatures of Colon Anastomotic Healing and Leakage in Mice.

Suresh, Kiran; Bhattacharyya, Sabarna; Carvajal, Jorge; Ghosh, Rajdeep; Zeisler-Diehl, Viktoria V.; Böckem, Vera et al. (2024): Effects of water stress on apoplastic barrier formation in soil grown roots differ from hydroponically grown roots: Histochemical, biochemical and molecular evidence. In: Plant, cell & environment 47 (12), S. 4917–4931. DOI: 10.1111/pce.15067.

Theodorou, Maria Rafailia; Yu, Jiangyan; Nikolka, Fabian; Zurkovic, Jelena; Wientjens, Chantal; Weiss, Patricia et al.: Anabolic lipid metabolism regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health: bioRxiv. Online verfügbar unter https://www.biorxiv.org/content/10.1101/2024.03.26.586766v1, zuletzt geprüft am 22.11.2024.

van Baarle, Lies; Simone, Veronica de; Schneider, Linda; Santhosh, Sneha; Abdurahiman, Saeed; Biscu, Francesca et al. (2024): IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer. In: Nat Commun 15 (1), S. 6079. DOI: 10.1038/s41467-024-50438-2.

Weiss, Felix D.; Alvarez, Yubell; Shakeri, Farhad; Sahu, Anshupa; Leka, Petro; Dernst, Alesja et al. (2024): Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice. In: Cell death and differentiation 31 (12), S. 1717–1729. DOI: 10.1038/s41418-024-01379-2.

Yao, Tongyan; Bucka, Franziska; Kögel‐Knabner, Ingrid; Knief, Claudia (2024): Organic matter type and soil texture shape prokaryotic communities during early‐stage soil structure formation. In: J. Plant Nutr. Soil Sci. 187 (1), S. 89–103. DOI: 10.1002/jpln.202300142.

2023

Fabian, Julia; Dworschak, Gabriel C.; Waffenschmidt, Lea; Schierbaum, Luca; Bendixen, Charlotte; Heilmann-Heimbach, Stefanie et al. (2023): Genome-wide identification of disease-causing copy number variations in 450 individuals with anorectal malformations. In: European journal of human genetics : EJHG 31 (1), S. 105–111. DOI: 10.1038/s41431-022-01216-5.

Frindte, Katharina; Kolb, Steffen; Sommer, Michael; Augustin, Jürgen; Knief, Claudia (2023): Spatial patterns of prokaryotic communities in kettle hole soils follow soil horizonation. In: Applied Soil Ecology 185, S. 104796. DOI: 10.1016/j.apsoil.2022.104796.

Funke, Kai; Einsfelder, Ulf; Hansen, Aylin; Arévalo, Lena; Schneider, Simon; Nettersheim, Daniel et al. (2023): Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours. In: British journal of cancer 128 (12), S. 2270–2282. DOI: 10.1038/s41416-023-02247-5.

Gressier, Elise; Schulte-Schrepping, Jonas; Petrov, Lev; Brumhard, Sophia; Stubbemann, Paula; Hiller, Anna et al. (2023): CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity. In: Nat Immunol 24 (6), S. 979–990. DOI: 10.1038/s41590-023-01517-x.

Hackstein, Carl-Philipp; Spitzer, Jasper; Symeonidis, Konstantinos; Horvatic, Helena; Bedke, Tanja; Steglich, Babett et al. (2023): Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. In: Journal of hepatology 79 (1), S. 150–166. DOI: 10.1016/j.jhep.2023.02.026.

Hanssen, Friederike; Gabernet, Gisela; Bäuerle, Famke; Stöcker, Bianca; Wiegand, Felix; Smith, Nicholas H. et al. (2023): NCBench: providing an open, reproducible, transparent, adaptable, and continuous benchmark approach for DNA-sequencing-based variant calling. In: F1000Res 12, S. 1125. DOI: 10.12688/f1000research.140344.2.

Ishorst, Nina; Henschel, Leonie; Thieme, Frederic; Drichel, Dmitriy; Sivalingam, Sugirthan; Mehrem, Sarah L. et al. (2023): Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores. In: Molecular genetics & genomic medicine 11 (3), e2109. DOI: 10.1002/mgg3.2109.

Leven, Patrick; Schneider, Reiner; Schneider, Linda; Mallesh, Shilpashree; Vanden Berghe, Pieter; Sasse, Philipp et al. (2023): β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery. In: Journal of neuroinflammation 20 (1), S. 255. DOI: 10.1186/s12974-023-02937-0.

Ludwig, Carolin Lisa Michaela; Bohleber, Simon; Lapp, Rebecca; Rebl, Alexander; Wirth, Eva Katrin; Langhammer, Martina et al. (2023): Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1. In: Journal of ovarian research 16 (1), S. 32. DOI: 10.1186/s13048-023-01113-5.

Siddiqui, Md Nurealam; Pandey, Kailash; Bhadhury, Suzan Kumer; Sadeqi, Bahman; Schneider, Michael; Sanchez-Garcia, Miguel et al. (2023): Convergently selected NPF2.12 coordinates root growth and nitrogen use efficiency in wheat and barley. In: The New phytologist 238 (5), S. 2175–2193. DOI: 10.1111/nph.18820.

Venneti, Sriram; Kawakibi, Abed Rahman; Ji, Sunjong; Waszak, Sebastian M.; Sweha, Stefan R.; Mota, Mateus et al. (2023): Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. In: Cancer discovery 13 (11), S. 2370–2393. DOI: 10.1158/2159-8290.CD-23-0131.

2022

Arévalo, Lena; Merges, Gina Esther; Schneider, Simon; Oben, Franka Enow; Neumann, Isabelle Sophie; Schorle, Hubert (2022): Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice. In: PLoS Genet 18 (6), e1010272. DOI: 10.1371/journal.pgen.1010272.

Braegelmann, C.; Niebel, D.; Ferring-Schmitt, S.; Fetter, T.; Landsberg, J.; Hölzel, M. et al. (2022): Epigallocatechin-3-gallate exhibits anti-inflammatory effects in a human interface dermatitis model-implications for therapy. In: Journal of the European Academy of Dermatology and Venereology : JEADV 36 (1), S. 144–153. DOI: 10.1111/jdv.17710.

Esser, Laura Kristin; Branchi, Vittorio; Shakeri, Farhad; Simon, Adrian Georg; Stephan, Carsten; Kristiansen, Glen et al. (2022): Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels. In: International journal of oncology 60 (2). DOI: 10.3892/ijo.2022.5310.

Funke, Kai; Düster, Robert; Wilson, Prince De-Graft; Arévalo, Lena; Geyer, Matthias; Schorle, Hubert (2022): Transcriptional CDK Inhibitors as Potential Treatment Option for Testicular Germ Cell Tumors. In: Cancers 14 (7). DOI: 10.3390/cancers14071690.

Hauke, Jan; Harter, Philipp; Ernst, Corinna; Burges, Alexander; Schmidt, Sandra; Reuss, Alexander et al. (2022): Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883). In: Journal of Medical Genetics 59 (3), S. 248–252. DOI: 10.1136/jmedgenet-2020-107353.

Karagiannis, Fotios; Peukert, Konrad; Surace, Laura; Michla, Marcel; Nikolka, Fabian; Fox, Mario et al. (2022): Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. In: Nature 609 (7928), S. 801–807. DOI: 10.1038/s41586-022-05128-8.

Leven, Patrick; Schneider, Reiner; Siemens, Kevin D.; Jackson, Walker S.; Wehner, Sven (2022): Application of a RiboTag-based approach to generate and analyze mRNA from enteric neural cells. In: Neurogastroenterology and motility 34 (7), e14309. DOI: 10.1111/nmo.14309.

Mallesh, Shilpashree; Hove, Anne S. ten; Schneider, Reiner; Schneiker, Bianca; Efferz, Patrik; Kalff, Jörg C. et al. (2022): Sympathetic Innervation Modulates Mucosal Immune Homeostasis and Epithelial Host Defense. In: Cells 11 (16). DOI: 10.3390/cells11162606.

Merges, Gina Esther; Meier, Julia; Schneider, Simon; Kruse, Alexander; Fröbius, Andreas Christian; Kirfel, Gregor et al. (2022): Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice. In: Development (Cambridge, England) 149 (12). DOI: 10.1242/dev.200330.

Niemann, Birte; Haufs-Brusberg, Saskia; Puetz, Laura; Feickert, Martin; Jaeckstein, Michelle Y.; Hoffmann, Anne et al. (2022): Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. In: Nature 609 (7926), S. 361–368. DOI: 10.1038/s41586-022-05041-0.

Schneider, Reiner; Leven, Patrick; Mallesh, Shilpashree; Breßer, Mona; Schneider, Linda; Mazzotta, Elvio et al. (2022): IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function. In: Commun Biol 5 (1), S. 811. DOI: 10.1038/s42003-022-03772-4.

Vennin, Constance; Hewel, Charlotte; Todorov, Hristo; Wendelmuth, Marlon; Radyushkin, Konstantin; Heimbach, André et al. (2022): A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice. In: Cells 11 (21). DOI: 10.3390/cells11213405.

Zietzer, Andreas; Breitrück, Nils; Düsing, Philip; Böhle, Sabrina; Klussmann, Jens Peter; Al-Kassou, Baravan et al. (2022): The lncRNA MRPL20-AS1 is associated with severe OSAS and downregulated upon hypoxic injury of endothelial cells. In: International journal of cardiology 369, S. 65–68. DOI: 10.1016/j.ijcard.2022.08.035.

Zillich, Lea; Poisel, Eric; Frank, Josef; Foo, Jerome C.; Friske, Marion M.; Streit, Fabian et al. (2022): Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum. In: Translational Psychiatry 12 (1), S. 190. DOI: 10.1038/s41398-022-01959-1.

2021

Beins, Eva C.; Beiert, Thomas; Jenniches, Imke; Hansen, Jan N.; Leidmaa, Este; Schrickel, Jan W.; Zimmer, Andreas (2021): Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress. In: Translational Psychiatry 11 (1), S. 164. DOI: 10.1038/s41398-021-01283-0.

Fradejas-Villar, Noelia; Zhao, Wenchao; Reuter, Uschi; Doengi, Michael; Ingold, Irina; Bohleber, Simon et al. (2021): Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4. In: Redox biology 48, S. 102188. DOI: 10.1016/j.redox.2021.102188.

Liao, Huan; Winkler, Jonas; Wißfeld, Jannis; Shahraz, Anahita; Klaus, Christine; Neumann, Harald (2021): Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice. In: Glia 69 (12), S. 2845–2862. DOI: 10.1002/glia.24073.

Mallesh, Shilpashree; Schneider, Reiner; Schneiker, Bianca; Lysson, Mariola; Efferz, Patrik; Lin, Eugene et al. (2021): Sympathetic Denervation Alters the Inflammatory Response of Resident Muscularis Macrophages upon Surgical Trauma and Ameliorates Postoperative Ileus in Mice. In: International Journal of Molecular Sciences 22 (13). DOI: 10.3390/ijms22136872.

Nitsch, Louisa; Petzinna, Simon; Zimmermann, Julian; Schneider, Linda; Krauthausen, Marius; Heneka, Michael T. et al. (2021): Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model. In: Journal of neuroinflammation 18 (1), S. 101. DOI: 10.1186/s12974-021-02140-z.

Pollecker, Karen; Sylvester, Marc; Voos, Wolfgang (2021): Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation. In: The Journal of biological chemistry 297 (4), S. 101134. DOI: 10.1016/j.jbc.2021.101134.

Scheiblich, Hannah; Dansokho, Cira; Mercan, Dilek; Schmidt, Susanne V.; Bousset, Luc; Wischhof, Lena et al. (2021): Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. In: Cell 184 (20), 5089-5106.e21. DOI: 10.1016/j.cell.2021.09.007.

Schmidt, Axel; Peters, Sophia; Knaus, Alexej; Sabir, Hemmen; Hamsen, Frauke; Maj, Carlo et al. (2021): TBK1 and TNFRSF13B mutations and an autoinflammatory disease in a child with lethal COVID-19. In: npj Genom. Med. 6 (1), S. 55. DOI: 10.1038/s41525-021-00220-w.

Schneider, Reiner; Leven, Patrick; Glowka, Tim; Kuzmanov, Ivan; Lysson, Mariola; Schneiker, Bianca et al. (2021): A novel P2X2-dependent purinergic mechanism of enteric gliosis in intestinal inflammation. In: EMBO molecular medicine 13 (1), e12724. DOI: 10.15252/emmm.202012724.

Seier, Johanna A.; Reinhardt, Julia; Saraf, Kritika; Ng, Susanna S.; Layer, Julian P.; Corvino, Dillon et al. (2021): Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma. In: Journal for immunotherapy of cancer 9 (5). DOI: 10.1136/jitc-2020-001335.

Shahraz, Anahita; Wißfeld, Jannis; Ginolhac, Aurélien; Mathews, Mona; Sinkkonen, Lasse; Neumann, Harald (2021): Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides. In: Glia 69 (1), S. 137–150. DOI: 10.1002/glia.23890.

Wegner, Julia; Zillinger, Thomas; Schlee-Guimaraes, Thais Marina; Bartok, Eva; Schlee, Martin (2021): An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1. In: Sci Rep 11 (1), S. 14983. DOI: 10.1038/s41598-021-94386-z.

Wißfeld, Jannis; Nozaki, Ichiro; Mathews, Mona; Raschka, Tamara; Ebeling, Christian; Hornung, Veit et al. (2021): Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype. In: Glia 69 (6), S. 1393–1412. DOI: 10.1002/glia.23968.