Virus Core Facility Bonn
AAVs are small, single-stranded DNA viruses that are capable of infecting a wide variety of dividing and quiescent cell types. In biomedical research, AAVs offer exceptional versatility, both in basic science and in the context of disease-related research. These tools enable the exploration of protein and cellular functions, biological networks, and developmental processes while also facilitating the creation of disease models and the identification of potential therapeutic targets.
Getting started
AAVs are valuable tools for delivering transgenes and altering gene expression in basic and disease-related biomedical research.
Contact
Contact our team now to find out more about the services of the Virus Core Facility and how they can be applied to your project.
Services
The Core Facility provides custom-made viral expression plasmids and adeno-associated viruses.
Do you have any questions?
FAQ
Find answers to frequently asked questions about core facility service billing and much more in our FAQ section.
Acknowledgement
Would you like to publish your results but are unsure how to acknowledge the support of the Core Facility? Please find detailed instructions here.
Needful Links
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Serotypes
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Promoters
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Cell types
Kim, Hyuntae; Melliti, Nesrine; Breithausen, Eva; Michel, Katrin; Colomer, Sara Ferrando; Poguzhelskaya, Ekaterina et al. (2024): Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells. In: Brain : a journal of neurology 147 (9), S. 3171–3188. DOI: 10.1093/brain/awae081.
Mitlasóczki, Bence; Gómez, Adrián Gutiérrez; Kamali, Midia; Babushkina, Natalia; Baues, Mayan; Kück, Laura et al. (2024): Region-specific spreading depolarization drives aberrant post-ictal behavior.
Domingos, Cátia; Müller, Franziska E.; Passlick, Stefan; Wachten, Dagmar; Ponimaskin, Evgeni; Schwarz, Martin K. et al. (2023): Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity. In: Cells 12 (2). DOI: 10.3390/cells12020331.
Leven, Patrick; Schneider, Reiner; Schneider, Linda; Mallesh, Shilpashree; Vanden Berghe, Pieter; Sasse, Philipp et al. (2023): β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery. In: Journal of neuroinflammation 20 (1), S. 255. DOI: 10.1186/s12974-023-02937-0.
Alich, Therese C.; Röderer, Pascal; Szalontai, Balint; Golcuk, Kurt; Tariq, Shahan; Peitz, Michael et al. (2022): Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings. In: Frontiers in cellular neuroscience 16, S. 1039957. DOI: 10.3389/fncel.2022.1039957.
Bohmbach, Kirsten; Masala, Nicola; Schönhense, Eva M.; Hill, Katharina; Haubrich, André N.; Zimmer, Andreas et al. (2022): An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning. In: Nat Commun 13 (1), S. 7932. DOI: 10.1038/s41467-022-35620-8.
Müller, Johannes Alexander; Betzin, Julia; Santos-Tejedor, Jorge; Mayer, Annika; Oprişoreanu, Ana-Maria; Engholm-Keller, Kasper et al. (2022): A presynaptic phosphosignaling hub for lasting homeostatic plasticity. In: Cell Reports 39 (3), S. 110696. DOI: 10.1016/j.celrep.2022.110696.
Niemann, Pia; Schiffer, Miriam; Malan, Daniela; Grünberg, Sabine; Roell, Wilhelm; Geisen, Caroline; Fleischmann, Bernd K. (2022): Generation and Characterization of an Inducible Cx43 Overexpression System in Mouse Embryonic Stem Cells. In: Cells 11 (4). DOI: 10.3390/cells11040694.
Royero, Pedro; Quatraccioni, Anne; Früngel, Rieke; Silva, Mariella Hurtado; Bast, Arco; Ulas, Thomas et al. (2022): Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase. In: Cell Reports 41 (10), S. 111757. DOI: 10.1016/j.celrep.2022.111757.
If you are interested in the services of the Virus Core Facility, please contact us:
Mail: anne.quatraccioni@uni-bonn.de
Phone: 0228 287 19346
If you would like to drop off or pick up plasmids and viruses, you can find us here.
Acknowledgements
Administration Medical Faculty
Documents
The Core Facilities thank the German Research Foundation for continuous support.
